On-Line Diffusion Profile of a Lipophilic Model Dye in Different Depths of a Hair Follicle in Human Scalp Skin

In skin and hair research, drug targeting to the hair follicle is of great interest in the treatment of skin diseases. The aim of this study is to visualize on-line the diffusion processes of a model fluorophore into the hair follicle at different depths using fresh human scalp skin and confocal laser scanning microscopy. Up to a depth of 500 μm in the skin, a fast increase of fluorescence is observed in the gap followed by accumulation of the dye in the hair cuticle. Penetration was also observed via the stratum corneum and the epidermis. Little label reached depths greater than 2000 μm. Fat cells accumulated the label fastest, followed by the cuticular area and the outer root sheath of the hair follicle. Sweat glands revealed very low staining, whereas the bulb at a depth of 4000 μm was visualized only by autofluorescence. From this study, we conclude that on-line visualization is a promising technique to access diffusion processes in deep skin layers even on a cellular level. Furthermore, we conclude that the gap and the cuticle play an important role in the initial diffusion period with the label in the cuticle originating from the gap

The Missing Luminous Blue Variables and the Bistability Jump

We discuss an interesting feature of the distribution of luminous blue variables on the H-R diagram, and we propose a connection with the bistability jump in the winds of early-type supergiants. There appears to be a deficiency of quiescent LBVs on the S Dor instability strip at luminosities between log L/Lsun = 5.6 and 5.8. The upper boundary, is also where the temperature-dependent S Dor instability strip intersects the bistability jump at about 21,000 K. Due to increased opacity, winds of early-type supergiants are slower and denser on the cool side of the bistability jump, and we postulate that this may trigger optically-thick winds that inhibit quiescent LBVs from residing there. We conduct numerical simulations of radiation-driven winds for a range of temperatures, masses, and velocity laws at log L/Lsun=5.7 to see what effect the bistability jump should have. We find that for relatively low stellar masses the increase in wind density at the bistability jump leads to the formation of a modest to strong pseudo photosphere -- enough to make an early B-type star appear as a yellow hypergiant. Thus, the proposed mechanism will be most relevant for LBVs that are post-red supergiants. Yellow hypergiants like IRC+10420 and rho Cas occupy the same luminosity range as the ``missing'' LBVs, and show apparent temperature variations at constant luminosity. If these yellow hypergiants do eventually become Wolf-Rayet stars, we speculate that they may skip the normal LBV phase, at least as far as their apparent positions on the HR diagram are concerned.Comment: 20 pages, 4 figs, accepted by Ap

The Infrared Continuum Sizes of Be Star Disks

We present an analysis of the near-infrared continuum emission from the circumstellar gas disks of Be stars using a radiative transfer code for a parametrized version of the viscous decretion disk model. This isothermal gas model creates predicted images that we use to estimate the HWHM emission radius along the major axis of the projected disk and the spatially integrated flux excess at wavelengths of 1.7, 2.1, 4.8, 9, and 18 ?m. We discuss in detail the effect of the disk base density, inclination angle, stellar effective temperature, and other physical parameters on the derived disk sizes and color excesses. We calculate color excess estimates relative to the stellar V -band flux for a sample of 130 Be stars using photometry from 2MASS and the AKARI infrared camera all-sky survey. The color excess relations from our models make a good match of the observed color excesses of Be stars. We also present our results on the projected size of the disk as a function of wavelength for the classical Be star ? Tauri, and we show that the model predictions are consistent with interferometric observations in the H, K', and 12 \mu m bands

Critical Micronutrients in Pregnancy, Lactation, and Infancy: Considerations on Vitamin D, Folic Acid, and Iron, and Priorities for Future Research

The Early Nutrition Academy and the European Commission-funded EURRECA Network of Excellence jointly sponsored a scientific workshop on critical micronutrients in pregnancy, lactation, and infancy. Current knowledge and unresolved questions on the supply of vitamin D, folic acid, and iron for pregnant women, lactating women, and infants, and their health effects were discussed. The question was addressed of whether, and under which circumstances, supplementation with these micronutrients in addition to usual dietary intakes is advisable. The workshop participants concluded that public health strategies for improving supplementation with these micronutrients in pregnancy, lactation, and infancy are required. Further research priorities should focus on adequately powered human intervention trials to obtain a stronger evidence base for the amounts of vitamin D, folic acid, and iron that have optimal effects on health. The conclusions of the workshop should help to inform the scientific community as well as public health policy strategies. Copyright (C) 2011 S. Karger AG, Base

The first X-ray survey of Galactic Luminous Blue Variables

Aims: The X-ray emission of massive stars has been studied when these objects are in their main-sequence phase, as well as in their Wolf-Rayet phase. However, the X-ray properties of the transitional Luminous Blue Variable (LBV) phase remain unknown. Methods: Using a dedicated but limited XMM survey as well as archival XMM and Chandra observations, we performed the first X-ray survey of LBVs: about half of the known LBVs or candidate LBVs are studied. Results: Apart from the well known X-ray sources eta Car and Cyg OB2 #12, four additional LBVs are detected in this survey, though some doubt remains on the association with the X-ray source for two of these. For the other LBVs, upper limits on the flux were derived, down to $\log[L_{\rm X}/L_{\rm BOL}]-9.4$ for PCyg. This variety in the strength of the X-ray emission is discussed, with particular emphasis on the potential influence of binarity.Comment: 13 pages, 2 figures, accepted by A&

Fundamental parameters of Be stars located in the seismology fields of COROT

In preparation for the COROT space mission, we determined the fundamental parameters (spectral type, temperature, gravity, vsini) of the Be stars observable by COROT in its seismology fields (64 Be stars). We applied a careful and detailed modeling of the stellar spectra, taking into account the veiling caused by the envelope, as well as the gravitational darkening and stellar flattening due to rapid rotation. Evolutionary tracks for fast rotators were used to derive stellar masses and ages. The derived parameters will be used to select Be stars as secondary targets (i.e. observed for 5 consecutive months) and short-run targets of the COROT mission. Furthermore, we note that the main part of our stellar sample is falling in the second half of the main sequence life time, and that in most cases the luminosity class of Be stars is inaccurate in characterizing their evolutionary status.Comment: 25 pages, 9 figures, Accepted for publication in A&

Hard X-ray emission in the star-forming region ON2: discovery with XMM-Newton

We obtained X-ray XMM-Newton observations of the open cluster Berkeley 87 and the massive star-forming region (SFR) ON 2. In addition, archival infrared Spitzer Space Telescope observations were used. It is likely that the SFR ON 2 and Berkeley 87 are at the same distance, 1.23 kpc, and hence are associated. The XMM-Newton observations detected X-rays from massive stars in Berkeley 87 as well as diffuse emission from the SFR ON 2. The two patches of diffuse X-ray emission are encompassed in the shell-like H II region GAL 75.84+0.40 in the northern part of ON 2 and in the ON 2S region in the southern part of ON 2. The diffuse emission from GAL 75.84+0.40 suffers an absorption column equivalent to A_V approx. 28 mag. Its spectrum can be fitted either with a thermal plasma model at T < 30 MK or by an absorbed power-law model with gamma; approx. -2.6. The X-ray luminosity of GAL 75.84+0.40 is L_X approx. 6 10^31 erg/s. The diffuse emission from ON 2S is adjacent to the ultra-compact H II (UCHII) region Cygnus 2N, but does not coincide with it or with any other known UCHII region. It has a luminosity of L_X approx. 4 10^31 erg/s. The spectrum can be fitted with an absorbed power-law model with gamma; approx.-1.4. We adopt the view of Turner and Forbes (1982) that the SFR ON 2 is physically associated with the massive star cluster Berkeley 87 hosting the WO type star WR 142. We discuss different explanations for the apparently diffuse X-ray emission in these SFRs. These include synchrotron radiation, invoked by the co-existence of strongly shocked stellar winds and turbulent magnetic fields in the star-forming complex, cluster wind emission, or an unresolved population of discrete sources.Comment: ApJ 2010, 712, 763. Reduced fig. resolution. Full resolution version is at http://www.astro.physik.uni-potsdam.de/research/abstracts/oskinova-ber87.htm

MN112: a new Galactic candidate Luminous Blue Variable

We report the discovery of a new Galactic candidate Luminous Blue Variable (cLBV) via detection of an infrared circular nebula and follow-up spectroscopy of its central star. The nebula, MN112, is one of many dozens of circular nebulae detected at $24 \mu$m in the {\it Spitzer Space Telescope} archival data, whose morphology is similar to that of nebulae associated with known (c)LBVs and related evolved massive stars. Specifically, the core-halo morphology of MN112 bears a striking resemblance to the circumstellar nebula associated with the Galactic cLBV GAL 079.29+00.46, which suggests that both nebulae might have a similar origin and that the central star of MN112 is a LBV. The spectroscopy of the central star showed that its spectrum is almost identical to that of the bona fide LBV P Cygni, which also supports the LBV classification of the object. To further constrain the nature of MN112, we searched for signatures of possible high-amplitude (\ga 1 mag) photometric variability of the central star using archival and newly obtained photometric data covering a 45 year period. We found that the B magnitude of the star was constant ($\simeq$ 17.1$\pm$0.3 mag) over this period, while in the I band the star brightened by $\simeq 0.4$ mag during the last 17 years. Although the non-detection of large photometric variability leads us to use the prefix `candidate' in the classification of MN112, we remind that the long-term photometric stability is not unusual for genuine LBVs and that the brightness of P Cygni remains relatively stable during the last three centuries.Comment: 6 pages, 3 figures, accepted to MNRA

Discovery of a detached HI gas shell surrounding alpha Orionis

We report the detection of the HI line at 21 cm in the direction of alpha Ori with the Nancay Radiotelescope and with the Very Large Array. The observations confirm the previous detection of HI emission centered on alpha Ori, but additionally reveal for the first time a quasi-stationary detached shell of neutral atomic hydrogen ~4 arcmin. in diameter (0.24 pc at a distance of 200 pc). The detached shell appears elongated in a direction opposite to the star's space motion. A simple model shows that this detached atomic gas shell can result from the collision of the stellar wind from alpha Ori with the local interstellar medium (ISM). It implies that alpha Ori has been losing matter at a rate of ~ 1.2x10^-6 solar masses per year for the past 8x10^4 years. In addition, we report the detection of atomic hydrogen associated with the far-infrared arc located 6 arcmin. north-east of alpha Ori, that has been suggested to trace the bow shock resulting from the motion of the star through the ISM. We report also the detection by the Galaxy Evolution Explorer (GALEX) of a far-UV counterpart to this arc.Comment: Accepted for publication in the Monthly Notices; version with full resolution figures available at http://aramis.obspm.fr/~lebertre/paper-alphaOri_MNRAS.pd

Spectral Energy Distributions of Be and Other Massive Stars

We present spectrophotometric data from 0.4 to 4.2 microns for bright, northern sky, Be stars and several other types of massive stars. Our goal is to use these data with ongoing, high angular resolution, interferometric observations to model the density structure and sky orientation of the gas surrounding these stars. We also present a montage of the H-alpha and near-infrared emission lines that form in Be star disks. We find that a simplified measurement of the IR excess flux appears to be correlated with the strength of emission lines from high level transitions of hydrogen. This suggests that the near-IR continuum and upper level line fluxes both form in the inner part of the disk, close to the star.Comment: 2010, PASP, 122, 37